Mining disease susceptibility genes through SNP analyses and expression profiling using MALDI-TOF mass spectrometry

被引：36

作者：

Tang, K ^{[1
]}

Oeth, P ^{[1
]}

Kammerer, S ^{[1
]}

Denissenko, MF ^{[1
]}

Ekblom, J ^{[1
]}

Jurinke, C ^{[1
]}

van den Boom, D ^{[1
]}

Braun, A ^{[1
]}

Cantor, CR ^{[1
]}

机构：

[1] Sequenom Inc, San Diego, CA 92121 USA

来源：

JOURNAL OF PROTEOME RESEARCH | 2004年 / 3卷 / 02期

关键词：

single nucleotide polymorphism; gene expression; differential allele expression; pharmacogenomics; MALDI; mass spectrometry;

D O I：

10.1021/pr034080s

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

To find genes that underlie disease susceptibilities, genome-wide single nucleotide polymorphisms (SNPs) have been analyzed using high-throughput matrix assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS). As a proof-of-concept for this approach, gene regions have been identified that were previously associated by others with certain diseases or traits. On the same technology platform, accurate and absolute transcriptional profiling can be performed and applied to allele expression analysis. Here, we provide a brief review of the technology and its applications to disease gene discovery.

引用

页码：218 / 227

页数：10

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