Retinoids and related compounds .19. Syntheses of 9E- and 9Z-locked retinoic acid analogues and their transcriptional activities as ligands for retinoic acid receptors and retinoid X receptors

被引：6

作者：

Katsuta, Y ^{[1
]}

Aoyama, Y ^{[1
]}

Osone, H ^{[1
]}

Wada, A ^{[1
]}

Ito, M ^{[1
]}

机构：

[1] KOBE WOMENS COLL PHARM,HIGASHINADA KU,KOBE,HYOGO 658,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 09期

关键词：

D O I：

10.1039/a606719k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel retinoic acid (RA) analogues, 9E-locked-RA 3 and 9Z-locked RA 4, have been synthesized in order to prohibit geometrical isomerization at the C(9)-C(10) double bond when these ligands interact with the retinoic acid receptor (RAR) and retinoid X receptor (RXR), Transcriptional activities of these analogues for RAR and RXR are also described.

引用

页码：1405 / 1410

页数：6

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