Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis

被引：2118

作者：

Condeelis, J

Pollard, JW

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

[2] Yeshiva Univ Albert Einstein Coll Med, Analyt Imaging Facil, Bronx, NY 10461 USA

[3] Yeshiva Univ Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

[4] Yeshiva Univ Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Ctr Study Reprod Biol & Womens Hlth, Bronx, NY 10461 USA

来源：

CELL | 2006年 / 124卷 / 02期

关键词：

D O I：

10.1016/j.cell.2006.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility. Recent studies reveal that direct communication between macrophages and tumor cells leads to invasion and egress of tumor cells into the blood vessels (intravasation). Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy.

引用

页码：263 / 266

页数：4

共 19 条

[1] Smoldering and polarized inflammation in the initiation and promotion of malignant disease
Balkwill, F
Charles, KA
Mantovani, A
[J]. CANCER CELL, 2005, 7 (03) : 211 - 217
[2] The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies
Bingle, L
Brown, NJ
Lewis, CE
[J]. JOURNAL OF PATHOLOGY, 2002, 196 (03) : 254 - 265
[3] The great escape: When cancer cells hijack the genes for chemotaxis and motility
Condeelis, J
Singer, RH
Segall, JE
[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2005, 21 : 695 - 718
[4] Inflammation and cancer
Coussens, LM
Werb, Z
[J]. NATURE, 2002, 420 (6917) : 860 - 867
[5] Tie2 identifies a hematopoietic monocytes required for tumor lineage of proangiogenic vessel formation and a mesenchymal population of pericyte progenitors
De Palma, M
Venneri, MA
Galli, R
Sergi, LS
Politi, LS
Sampaolesi, M
Naldini, L
[J]. CANCER CELL, 2005, 8 (03) : 211 - 226
[6] An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis
Giraudo, E
Inoue, M
Hanahan, D
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (05) : 623 - 633
[7] The hallmarks of cancer
Hanahan, D
Weinberg, RA
[J]. CELL, 2000, 100 (01) : 57 - 70
[8] NFκB:: Linking inflammation and immunity to cancer development and progression
Karin, M
Greten, FR
[J]. NATURE REVIEWS IMMUNOLOGY, 2005, 5 (10) : 749 - 759
[9] Tumor-associated macrophages in breast cancer
Leek, RD
Harris, AL
[J]. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2002, 7 (02) : 177 - 189
[10] Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
Lin, EY
Nguyen, AV
Russell, RG
Pollard, JW
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (06) : 727 - 739

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