On synthesis and properties of hypericin-porphyrin hybrids

被引：3

作者：

Aigner, Stefan ^{[1
]}

Falk, Heinz ^{[1
]}

机构：

[1] Inst Organ Chem, Linz, Austria

来源：

MONATSHEFTE FUR CHEMIE | 2008年 / 139卷 / 12期

关键词：

Hypericin; Porphyrin; Singlet oxygen; Reactive oxidative species; Absorption;

D O I：

10.1007/s00706-008-0940-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two diastereomeric tetraphenylporphyrinyl-omega-hypericinyl-ethylenes were prepared and their properties investigated. The (Z)-diastereomer displayed an even higher photosensitization of singlet oxygen and/or reactive oxygen species than hypericin, whereas the (E)-configured derivative showed a somewhat weaker effect. Accordingly, hybridization of hypericin and porphyrin chromophores seems to be a promising target for the development of novel sensitizers for photodynamic therapy.

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收藏

页码：1513 / 1518

页数：6

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