Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila

被引：253

作者：

Dobrosotskaya, IY ^{[1
]}

Seegmiller, AC ^{[1
]}

Brown, MS ^{[1
]}

Goldstein, JL ^{[1
]}

Rawson, RB ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA

来源：

SCIENCE | 2002年 / 296卷 / 5569期

关键词：

D O I：

10.1126/science.1071124

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Animal cells exert exquisite control over the physical and chemical properties of their membranes, but the mechanisms are obscure. We show that phosphatidylethanolamine, the major phospholipid in Drosophila, controls the release of sterol regulatory element-binding protein (SREBP) from Drosophila cell membranes, exerting feedback control on the synthesis of fatty acids and phospholipids. The finding that SREBP processing is controlled by different lipids in mammals and flies (sterols and phosphatidylethanolamine, respectively) suggests that an essential function of SREBP is to monitor cell membrane composition and to adjust lipid synthesis accordingly.

引用

页码：879 / 883

页数：5

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