Oral contraceptives alter circadian rhythm parameters of cortisol, melatonin, blood pressure, heart rate, skin blood flow, transepidermal water loss, and skin amino acids of healthy young women

被引:62
作者
Reinberg, AE
Touitou, Y
Soudant, T
Bernard, D
Bazin, R
Mechkouri, M
机构
[1] FDN ADOLPHE DE ROTHSCHILD,UNITE CHRONOBIOL & CHRONOTHERAPIE,F-75940 PARIS 19,FRANCE
[2] UNIV PARIS 06,LAB BIOCHIM MED,F-75634 PARIS 13,FRANCE
[3] LOREAL,LAB RECH APPL & DEV,F-94550 CHEVILLY LARUE,FRANCE
关键词
circadian rhythms; blood pressure; cortisol; melatonin; oral contraceptives; skin blood flow; transepidermal water loss;
D O I
10.3109/07420529609012653
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Sixteen healthy women users and nonusers of oral contraceptives (OC) volunteered to document a set of circadian rhythms. Nine were taking OC providing ethynyl estradiol (0.03-0.05 mg/24h, 21 days/month) combined with DL- Or L-norgestrel or norethisterone. There was no group difference (p > 0.05) in median age (22 years), weight (57 kg), and height (162) cm). Data were obtained at fixed hours, 5 times/24h, during a 48-h span, in November. (Day activity from congruent to 08:00 to congruent to 23:00 h and night rest). Environmental conditions were controlled, using air-conditioned rooms of constant temperature (26 degrees+/-0.5) and relative humidity 45%+/-1. Both cosinor and ANOVA were used for statistical analyses. All circadian rhythms were validated with one exception: that of salivary melatonin was not detected in OC users. The 24h mean (M) exhibited group differences for certain variables: M was greater in OC than non-OC users for systolic blood pressure (p < 0.0001), heart rate (p < 0.01), skin blood flow (p < 0.04), and transepidermal water loss (p < 0.02). M was lower in OC than non-OC users in salivary cortisol (p < 0.04) and skin amino acids (p < 0.003). No group difference was detected in any other documented rhythms: diastolic blood pressure, grip strength of both hands, oral temperature, self-rated fatigue, and the skin variables of urea, lactate, triglycerides, and acid phosphatase activity.
引用
收藏
页码:199 / 211
页数:13
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