Asymmetric synthesis of non-natural homologues of lysine

被引：19

作者：

Kennedy, KJ

Lundquist, JT

Simandan, TL

Beeson, CC

Dix, TA

机构：

[1] MED UNIV S CAROLINA, DEPT PHARMACEUT SCI, CHARLESTON, SC 29425 USA

[2] UNIV WASHINGTON, DEPT CHEM, SEATTLE, WA 98195 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(97)00335-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of non-natural amino acid homologues of L- and D-lysine have been synthesized and protected for use in solid-phase peptide synthesis. With these residues, electrostatics and hydrophobicity of peptides can be enhanced or altered. (C) 1997 Elsevier Science Ltd.

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页码：1937 / 1940

页数：4

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