Mother-to-child discordance in HLA-G exon 2 is associated with a reduced risk of perinatal HIV-1 transmission

被引：21

作者：

Aikhionbare, FO ^{[1
]}

Hodge, T

Kuhn, L

Bulterys, M

Abrams, EJ

Bond, VC

机构：

[1] Morehouse Sch Med, Dept Microbiol, Atlanta, GA 30310 USA

[2] Morehouse Sch Med, Dept Biochem, Atlanta, GA 30310 USA

[3] Morehouse Sch Med, Dept Immunol, Atlanta, GA 30310 USA

[4] Morehouse Sch Med, Dept Surg, Atlanta, GA 30310 USA

[5] Ctr Dis Control & Prevent, Immunol Branch, Div HIV AIDS & TB, Atlanta, GA 30333 USA

[6] Ctr Dis Control & Prevent, Epidemiol Branch, Div HIV AIDS Prevent, Atlanta, GA 30333 USA

[7] Columbia Univ, New York, NY 10032 USA

[8] Columbia Univ Coll Phys & Surg, Harlem Hosp Ctr, New York, NY 10032 USA

来源：

AIDS | 2001年 / 15卷 / 16期

关键词：

D O I：

10.1097/00002030-200111090-00019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Definitive genetic parameters correlating with mother-to-child transmission (MCT) of HIV have not been fully established. We screened for the potential correlation between HLA-G variants and MCT, in a cohort of mother-child pairs. Discordance in exon 2 of HLA-G was significantly more common among non-transmitting (93%) than transmitting mother-child pairs (40%). Our results suggest that mother-child pairs both carrying the identical mutation in HLA-G exon 2 may be at higher risk of MCT of HIV-1.

引用

页码：2196 / 2198

页数：3

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