Investigations on the thermal stability of a diazonium ion on solid support

We have synthesised a diazonium ion starting from 2-chloro-5-aminobenzyl alcohol, and investigated in detail its thermal stability. The DSC runs at seven different heating rates give evidence of a single decomposition reaction occurring around 90-120degreesC, whose kinetics were analysed by both the iso- conversional differential and integral method, the invariant kinetic parameters method, Kissinger's method, and a differential isothermal method. All of these :methods led to similar values for the kinetic parameters and showed that the first-order mechanism fits the data best. The values of the kinetic parameters were further used for calculating the half-life time of the ion at various temperatures. The result of the stability prediction at 60degreesC was compared with that of an analytical isothermal test yielding a good agreement between prediction and experiment. (C) 2002 Elsevier Science Ltd. All rights reserved.