Long-Term Impact of Multifactorial Treatment on New-Onset Diabetes and Related Cardiovascular Events in Metabolic Syndrome: A Post Hoc ATTEMPT Analysis

被引:26
作者
Athyros, Vassilios G. [2 ]
Elisaf, Moses S. [3 ]
Alexandrides, Theodore [4 ]
Achimastos, Apostolos [5 ]
Ganotakis, Emmanouel [6 ]
Bilianou, Eleni [7 ]
Karagiannis, Asterios [2 ]
Liberopoulos, Evangelos N. [3 ]
Tziomalos, Konstantinos [2 ]
Mikhailidis, Dimitri P. [1 ]
机构
[1] UCL, Sch Med, Dept Clin Biochem, London NW3 2QG, England
[2] Aristotle Univ Thessaloniki, Propedeut Med Sch 2, Dept Internal Med, GR-54006 Thessaloniki, Greece
[3] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece
[4] Univ Patras, Sch Med, Rio Hosp, Dept Internal Med,Div Endocrinol, GR-26110 Patras, Greece
[5] Univ Athens, Sch Med, Sotiria Gen Hosp, Dept Med 3, GR-11527 Athens, Greece
[6] Univ Crete, Sch Med, Dept Internal Med, Iraklion, Greece
[7] Tzanio State Hosp, Dept Cardiol, Piraeus, Greece
关键词
new-onset diabetes; metabolic syndrome; multifactorial treatment; atorvastatin; cardiovascular disease risk; RENIN-ANGIOTENSIN SYSTEM; POPULATION-BASED INCIDENCE; LIFE-STYLE INTERVENTION; RISK-FACTORS; ANTIHYPERTENSIVE THERAPY; CARDIAC OUTCOMES; VASCULAR-DISEASE; OBESE-PATIENTS; PREVENTION; MELLITUS;
D O I
10.1177/0003319711421341
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
This post hoc analysis of the Assessing The Treatment Effect in Metabolic Syndrome Without Perceptible diabeTes (ATTEMPT) study assesses the 31/2 year incidence of new-onset diabetes (NOD) and related cardiovascular disease (CVD) events in patients with metabolic syndrome (MetS), after multifactorial (lifestyle and drug, including atorvastatin) intervention. Patients were randomized to group A (low-density lipoprotein cholesterol [LDL-C] target <100 mg/dL) and group B (<130 mg/dL). The incidence of NOD during the 42-month follow-up was very low, 0.83 to 1.00/100 patient-years in patients with MetS and MetS with impaired fasting glucose, respectively. Older age, increased waist circumference, and persistent MetS were determinants of NOD. One CVD nonfatal event occurred in the 28 patients with NOD. Our findings suggest that treating the characteristics of MetS is achievable and beneficial. New-onset diabetes incidence and CVD events were negligible and not different from what is expected in the general population.
引用
收藏
页码:358 / 366
页数:9
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