Regulation of the intercellular adhesin locus regulator (icaR) by SarA, σB, and IcaR in Staphylococcus aureus

被引：52

作者：

Cerca, Nuno ^{[1
]}

Brooks, Jamie L. ^{[1
]}

Jefferson, Kimberly K. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Richmond, VA 23928 USA

来源：

JOURNAL OF BACTERIOLOGY | 2008年 / 190卷 / 19期

关键词：

D O I：

10.1128/JB.00482-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The staphylococcal accessory regulator SarA and the alternative sigma factor sigma(B) have been previously identified as positive regulators, and IcaR as a negative regulator, of icaADBC expression. Here, we show that in Staphylococcus aureus SarA and sigma(B) are also required for icaR expression and that IcaR does not have a significant effect on its own expression.

引用

页码：6530 / 6533

页数：4

共 28 条

[1] Allelic replacement in Staphylococcus aureus with inducible counter-selection [J].

Bae, T ;

Schneewind, O .

PLASMID, 2006, 55 (01) :58-63

[2] Mutation of sarA in Staphylococcus aureus limits biofilm formation [J].

Beenken, KE ;

Blevins, JS ;

Smeltzer, MS .

INFECTION AND IMMUNITY, 2003, 71 (07) :4206-4211

[3] Microarray-based analysis of the Staphylococcus aureus σB regulon [J].

Bischoff, M ;

Dunman, P ;

Kormanec, J ;

Macapagal, D ;

Murphy, E ;

Mounts, W ;

Berger-Bächi, B ;

Projan, S .

JOURNAL OF BACTERIOLOGY, 2004, 186 (13) :4085-4099

[4]

BRUCKNER R, 1993, J BACTERIOL, V175, P851

[5] agr-Genotyping and transcriptional analysis of biofilm-producing Staphylococcus aureus [J].

Cafiso, Viviana ;

Bertuccio, Taschia ;

Santagati, Maria ;

Demelio, Vanessa ;

Spina, Daniela ;

Nicoletti, Giuseppe ;

Stefani, Stefania .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2007, 51 (01) :220-227

[6] Effect of growth conditions on poly-N-acetylglucosamine expression and biofilm formation in Escherichia coli [J].

Cerca, Nuno ;

Jefferson, Kimberly K. .

FEMS MICROBIOLOGY LETTERS, 2008, 283 (01) :36-41

[7] Role of the distal sarA promoters in SarA expression in Staphylococcus aureus [J].

Cheung, AL ;

Manna, AC .

INFECTION AND IMMUNITY, 2005, 73 (07) :4391-4394

[8]

Conlon KM, 2002, FEMS MICROBIOL LETT, V216, P171, DOI 10.1016/S0378-1097(02)01031-5

[9] icaR encodes a transcriptional repressor involved in environmental regulation of ica operon expression and biofilm formation in Staphylococcus epidermidis [J].

Conlon, KM ;

Humphreys, H ;

O'Gara, JP .

JOURNAL OF BACTERIOLOGY, 2002, 184 (16) :4400-4408

[10] The intercellular adhesion (ica) locus is present in Staphylococcus aureus and is required for biofilm formation [J].

Cramton, SE ;

Gerke, C ;

Schnell, NF ;

Nichols, WW ;

Götz, F .

INFECTION AND IMMUNITY, 1999, 67 (10) :5427-5433

← 1 2 3 →