Applications of 31P NMR spectroscopy in development of M(Duphos)-catalyzed asymmetric synthesis of P-stereogenic phosphines (M = Pt or Pd)

被引：63

作者：

Glueck, David S. ^{[1
]}

机构：

[1] Dartmouth Coll, Dept Chem, Burke Lab 6128, Hanover, NH 03755 USA

来源：

COORDINATION CHEMISTRY REVIEWS | 2008年 / 252卷 / 21-22期

基金：

美国国家科学基金会;

关键词：

P-31; NMR; Catalysis; Platinum; Palladium; Chiral phosphines;

D O I：

10.1016/j.ccr.2007.12.023

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This perspective describes the use of P-31 NMR spectroscopy in an ongoing research project on enantioselective P-C bond formation catalyzed by platinum and palladium Duphos complexes. This technique was used to characterize catalyst precursors, intermediates and products, to determine equilibrium and rate constants, and to measure the enantiomeric excess (ee) of the P-stereogenic phosphine products. Applications of P-31 NMR spectroscopy in problem-solving and identifying unexpected products, as well as the analysis of an unusual and esthetically pleasing spectrum, are also discussed. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：2171 / 2179

页数：9

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