CD8 lineage commitment in the absence of CD8

被引:66
作者
Goldrath, AW
Hogquist, KA
Bevan, MJ
机构
[1] UNIV WASHINGTON, DEPT IMMUNOL, SEATTLE, WA 98195 USA
[2] UNIV WASHINGTON, HOWARD HUGHES MED INST, SEATTLE, WA 98195 USA
[3] UNIV MINNESOTA, SCH MED, DEPT PATHOL & LAB MED, MINNEAPOLIS, MN 55455 USA
关键词
D O I
10.1016/S1074-7613(00)80351-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The absence of cytotoxic T lymphocyte activity and the failure of MHC class I-restricted T cell receptor (TCR) transgenic thymocytes to mature in CD8 alpha-deficient mice suggest that CD8 may be essential for CD8 lineage commitment. We report that variants of the antigenic peptide that delete TCR transgenic thymocytes from CD8 wild-type but not CD8 alpha-deficient mice can restore positive selection of CD8 lineage cells in the absence of CD8. The positively selected cells down-regulate CD4, up-regulate TCR, respond to the antigenic peptide, and express CD8 beta mRNA. Interestingly, there was no enhanced selection of CD4(+) T cells, implying that the TCR-MHC interaction, even in the absence of CD8, provided instructive signaling for commitment to the CD8 lineage. Our results are discussed in terms of recent models of T cell lineage commitment.
引用
收藏
页码:633 / 642
页数:10
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