Orofacial clefts in Hungary - Epidemiological and genetic data, primary prevention

被引：20

作者：

Czeizel, AE

Hirschberg, J

机构：

[1] WHO,NATL INST PUBL HLTH,DEPT HUMAN GENET & TERATOL,GENEVA,SWITZERLAND

[2] MADARASZ CHILDRENS HOSP,DEPT OTORHINOLARYNGOL,BUDAPEST,HUNGARY

[3] MADARASZ CHILDRENS HOSP,CLEFT PALATE CTR,BUDAPEST,HUNGARY

来源：

FOLIA PHONIATRICA ET LOGOPAEDICA | 1997年 / 49卷 / 3-4期

关键词：

orofacial clefts; cleft lip; cleft palate; epidemiology; genetics; prevention;

D O I：

10.1159/000266446

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

The occurrences (birth prevalences) of different types of isolated and multiple orofacial clefts are known in Hungary. The empiric risk figures in the first-degree relatives of probands with cleft lip +/- cleft palate, cleft palate, Robin sequence and multiple congenital abnormalities including orofacial clefts as component defects were also determined. Finally the recent controversial data concerning the primary prevention of isolated orofacial clefts by periconceptional folic acid-containing multivitamins are summarized.

引用

页码：111 / 116

页数：6

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