Expression of nitric oxide system in clinically evaluated cases of Alzheimer's disease

被引：105

作者：

Fernández-Vizarra, P ^{[1
]}

Fernández, AP ^{[1
]}

Castro-Blanco, S ^{[1
]}

Encinas, JM ^{[1
]}

Serrano, J ^{[1
]}

Bentura, ML ^{[1
]}

Muñoz, P ^{[1
]}

Martínez-Murillo, R ^{[1
]}

Rodrigo, J ^{[1
]}

机构：

[1] CSIC, Inst Cajal, Dept Cell Biol & Neuroanat, E-28002 Madrid, Spain

来源：

NEUROBIOLOGY OF DISEASE | 2004年 / 15卷 / 02期

关键词：

Alzheimer's disease; immunocytochemistry; nitric oxide synthase; nitrotyrosine; human brain;

D O I：

10.1016/j.nbd.2003.10.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression of neuronal nitric oxide (nNOS) and inducible nitric oxide (iNOS) as isoforms of the nitric oxide synthase (NOS) as well as nitrotyrosine as an end product of protein nitration was analyzed in sections of temporal cortex taken from postmortem brains of patients with Alzheimer's disease (AD). The patients were evaluated by the Clinical Dementia Rating scale (CDR0-CDR3) and studied in the Memory and Aging Project (MAP) of the Washington University Alzheimer Disease Research Center (ADCR). With the use of immunocytochemical procedures, neurons immunoreactive to nNOS were found to show large and small multipolar and pyramidal morphologies over the entire chronic AD evolution. The iNOS and nitrotyrosine immunoreactivities were also found in pyramidal-like cortical neurons and glial cells. Here, we speculate on the interaction among all specific neurodegenerative changes in AD and nitric oxide as an additional contribution to neuronal death in AD. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：287 / 305

页数：19

共 96 条

[1] Effects of oxygen and glucose deprivation on the expression and distribution of neuronal and inducible nitric oxide synthases and on protein nitration in rat cerebral cortex [J].

Alonso, D ;

Serrano, J ;

Rodríguez, I ;

Ruíz-Cabello, J ;

Fernández, AP ;

Encinas, JM ;

Castro-Blanco, S ;

Bentura, ML ;

Santacana, M ;

Richart, A ;

Fernández-Vizarra, P ;

Uttenthal, LO ;

Rodrigo, J .

JOURNAL OF COMPARATIVE NEUROLOGY, 2002, 443 (02) :183-200

[2]

Alzheimer A., 1907, ALLG Z PSYCHIAT, V64, P146, DOI DOI 10.1002/CA.980080612

[3]

[Anonymous], [No title captured]

[4] β-Amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology [J].

Apelt, J ;

Schliebs, R .

BRAIN RESEARCH, 2001, 894 (01) :21-30

[5] DEXAMETHASONE SUPPRESSION TEST AND SERUM PROLACTIN IN DEMENTIA DISORDERS [J].

BALLDIN, J ;

GOTTFRIES, CG ;

KARLSSON, I ;

LINDSTEDT, G ;

LANGSTROM, G ;

WALINDER, J .

BRITISH JOURNAL OF PSYCHIATRY, 1983, 143 (SEP) :277-281

[6] Oxidative damage and tyrosine nitration from peroxynitrite [J].

Beckman, JS .

CHEMICAL RESEARCH IN TOXICOLOGY, 1996, 9 (05) :836-844

[7]

Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424

[8]

BENZI G, 1995, NEUROBIOL AGING, V16, P4661

[9] MILD SENILE DEMENTIA OF THE ALZHEIMER TYPE .4. EVALUATION OF INTERVENTION [J].

BERG, L ;

MILLER, JP ;

BATY, J ;

RUBIN, EH ;

MORRIS, JC ;

FIGIEL, G .

ANNALS OF NEUROLOGY, 1992, 31 (03) :242-249

[10]

BERG L, 1988, PSYCHOPHARMACOL BULL, V24, P637

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