How BAD phosphorylation is good for survival

被引:207
作者
Downward, J [1 ]
机构
[1] Imperial Canc Res Fund, London WC2A 3PX, England
关键词
D O I
10.1038/10026
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
BAD is a pro-apoptotic member of the Bcl-2 family that is tightly regulated by survival factors. Several major signalling pathways influence cell death through their direct effects on the phosphorylation state of BAD.
引用
收藏
页码:E33 / E35
页数:3
相关论文
共 15 条
[1]   The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136 [J].
Blume-Jensen, P ;
Janknecht, R ;
Hunter, T .
CURRENT BIOLOGY, 1998, 8 (13) :779-782
[2]   Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor [J].
Brunet, A ;
Bonni, A ;
Zigmond, MJ ;
Lin, MZ ;
Juo, P ;
Hu, LS ;
Anderson, MJ ;
Arden, KC ;
Blenis, J ;
Greenberg, ME .
CELL, 1999, 96 (06) :857-868
[3]   Regulation of cell death protease caspase-9 by phosphorylation [J].
Cardone, MH ;
Roy, N ;
Stennicke, HR ;
Salvesen, GS ;
Franke, TF ;
Stanbridge, E ;
Frisch, S ;
Reed, JC .
SCIENCE, 1998, 282 (5392) :1318-1321
[4]   Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery [J].
Datta, SR ;
Dudek, H ;
Tao, X ;
Masters, S ;
Fu, HA ;
Gotoh, Y ;
Greenberg, ME .
CELL, 1997, 91 (02) :231-241
[5]  
delPeso L, 1997, SCIENCE, V278, P687
[6]   Mechanisms and consequences of activation of protein kinase B/Akt [J].
Downward, J .
CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (02) :262-267
[7]   Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A [J].
Harada, H ;
Becknell, B ;
Wilm, M ;
Mann, M ;
Huang, LJS ;
Taylor, SS ;
Scott, JD ;
Korsmeyer, SJ .
MOLECULAR CELL, 1999, 3 (04) :413-422
[8]  
Kitada S, 1998, AM J PATHOL, V152, P51
[9]  
Korsmeyer SJ, 1999, CANCER RES, V59, p1693S
[10]   Dissociation of cytokine-induced phosphorylation of bad and activation of PKB/akt: Involvement of MEK upstream of bad phosphorylation [J].
Scheid, MP ;
Duronio, V .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7439-7444