A high sensitivity differential scanning calorimetry study of the interaction between poloxamers and dimyristoylphosphatidylcholine and dipalmitoylphosphatidylcholine liposomes

被引：34

作者：

Castile, JD ^{[1
]}

Taylor, KMG ^{[1
]}

Buckton, G ^{[1
]}

机构：

[1] Univ London, Sch Pharm, Dept Pharmaceut, Ctr Mat Sci, London WC1N 1AX, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1999年 / 182卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

freeze-thaw; high sensitivity differential scanning calorimetry; liposome; phase transition temperature; phospholipid; poloxamer; surfactant;

D O I：

10.1016/S0378-5173(99)00069-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

High sensitivity differential scanning calorimetry (HSDSC) has been used to measure the thermal behaviour of dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylcholine (DPPC) liposomes to which poloxamer surfactants P338 or P407 had been added during or after preparation. The phospholipid pre-transition was more sensitive than the main transition to the association of poloxamers with liposomal bilayers. Poloxamers reduced the enthalpy of the pre-transition of liquid-crystalline state DMPC and DPPC MLVs but not that of gel state DPPC MLVs. Freezing and thawing DMPC and DPPC liposomes in the presence of poloxamers was shown to increase their interaction with the liposomal bilayers. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：101 / 110

页数：10

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