The atypical protein kinase C (PMC) member PKC-zeta has been implicated in several signal transduction pathways regulating differentiation, proliferation or apoptosis of mammalian cells, We report here the identification of a cytoplasmic and membrane-associated protein that we name zeta-interacting protein (ZIP) and that interacts with the regulatory domain of PKC-zeta but not classic PKCs, The structural motifs in ZIP include a recently defined ZZ zinc finger as a potential protein binding module, two PEST sequences and a novel putative protein binding motif with the consensus sequence YXDEDX5SDEE/D. ZIP binds to the pseudosubstrate region in the regulatory domain of PKC-zeta and is phosphorylated by PKC-zeta in vitro. ZIP dimerizes via the same region that promotes binding to PKC-zeta suggesting a competitive situation between ZIP:ZIP and ZIP:PKC-zeta complexes, In the absence of PKC-zeta proper subcellular localization of ZIP is impaired and we show that intracellular targeting of ZIP is dependent on a balanced interaction with PKC-zeta. Taking into account the recent isolation of ZIP by others in different contexts we propose that ZIP may function as a scaffold protein linking PKC-zeta to protein tyrosine kinases and cytokine receptors.
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UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
DiazMeco, MT
Municio, MM
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UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
Municio, MM
Frutos, S
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UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
Frutos, S
Sanchez, P
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UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
Sanchez, P
Lozano, J
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UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
Lozano, J
Sanz, L
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UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
Sanz, L
Moscat, J
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UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
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UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
DiazMeco, MT
Municio, MM
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机构:
UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
Municio, MM
Frutos, S
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机构:
UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
Frutos, S
Sanchez, P
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h-index: 0
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UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
Sanchez, P
Lozano, J
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h-index: 0
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UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
Lozano, J
Sanz, L
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h-index: 0
机构:
UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN
Sanz, L
Moscat, J
论文数: 0引用数: 0
h-index: 0
机构:
UNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAINUNIV AUTONOMA MADRID,CONSEJO SUPER INVEST CIENT,CTR BIOL MOL,MADRID 28049,SPAIN