The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134

被引：106

作者：

Bicker, Silvia ^{[1
]}

Khudayberdiev, Sharof ^{[1
]}

Weiss, Kerstin ^{[1
]}

Zocher, Kathleen ^{[1
]}

Baumeister, Stefan ^{[2
]}

Schratt, Gerhard ^{[1
]}

机构：

[1] Univ Marburg, Inst Physiol Chem, Biochem Pharmakol Ctr Marburg, D-35032 Marburg, Germany

[2] Univ Marburg, Fachbereich Biol Prot Analyt, D-35032 Marburg, Germany

来源：

GENES & DEVELOPMENT | 2013年 / 27卷 / 09期

关键词：

dendritic transport; DHX36; precursor-microRNA; protein synthesis; synaptic plasticity; MESSENGER-RNA; MICRORNA BIOGENESIS; MOUSE-BRAIN; TRANSLATION; DENDRITOGENESIS; PLASTICITY; TRANSPORT; REVEALS; PATHWAY; MEMORY;

D O I：

10.1101/gad.211243.112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SpecificmicroRNAs (miRNAs), includingmiR-134, localize to neuronal dendrites, where they control synaptic protein synthesis and plasticity. However, the mechanism of miRNA transport is unknown. We found that the neuronal precursor-miRNA-134 (pre-miR-134) accumulates in dendrites of hippocampal neurons and at synapses in vivo. Dendritic localization of pre-miR-134 is mediated by the DEAH-box helicase DHX36, which directly associates with the pre-miR-134 terminal loop. DHX36 function is required for miR-134-dependent inhibition of target gene expression and the control of dendritic spine size. Dendritically localized pre-miR-134 could provide a local source of miR-134 that can be mobilized in an activity-dependent manner during plasticity.

引用

页码：991 / 996

页数：6

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