Functional Roles for Exosomal MicroRNAs in the Tumour Microenvironment

被引：69

作者：

Bell, Emma ^{[1
]}

Taylor, Molly A. ^{[2
]}

机构：

[1] AstraZeneca, Personalised Healthcare & Biomarkers, iMed, Cambridge Sci Pk, Cambridge CB4 0FZ, England

[2] AstraZeneca, Oncol iMed Biosci, Cambridge CB2 0RE, England

来源：

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL | 2017年 / 15卷

关键词：

MicroRNA; Extracellular vesicles; Tumour microenvironment; EXTRACELLULAR VESICLES; PROMOTES ANGIOGENESIS; STROMAL CELLS; CANCER; RNAS; MICROVESICLES; EXPRESSION; SECRETION; TRANSFERRIN; HALLMARKS;

D O I：

10.1016/j.csbj.2016.10.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Extracellular microRNAs are released from cells both passively and actively. The presence of these microRNAs in the tumour microenvironment (TME) can significantly impact on the plasticity of cancer cells leading to the promotion of metastatic and angiogenic processes. These extracellular microRNAs can act not only on other cancer cells, but also cells present in the TME, such as immune cells, endothelial cells, fibroblasts, and others acting to subvert the host immune system and drive tumour progression. In this review we highlight the current understanding of both the mechanisms by which microRNAs are released from tumour cells and the downstream functional effects that extracellular microRNAs have on recipient cells. (C) 2016 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.

引用

页码：8 / 13

页数：6

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