Randomized clinical trial of PCR-determined human papillomavirus detection methods: Self-sampling versus clinician-directed-Biologic concordance and women's preferences

被引:95
作者
Harper, DM
Noll, WW
Belloni, DR
Cole, BF
机构
[1] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Obstet & Gynecol, Hanover, NH 03756 USA
[2] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Pathol, Hanover, NH 03756 USA
[3] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Community & Family Med, Hanover, NH 03756 USA
关键词
human papillomavirus; screening; self-sampling; swab; acceptability;
D O I
10.1067/mob.2002.121076
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: The purpose of this study was to compare the high-risk human papillomavirus detection rates from self-sampled swabs and tampons with standard clinician-directed speculum sampling and to assess women's acceptance of self-sampling methods. STUDY DESIGN: One hundred three women who required a colposcopy underwent order randomization of the human papillomavirus sampling technique. Kappa and McNemar test statistical results were used to measure the agreement between clinician-directed and self-sampling techniques for high-risk types of human papillomavirus and the acceptance of self-sampling techniques. RESULTS: All self-directed samplings were equivalent to clinician sampling for all cervical intraepithelial neoplasia disease states. High-risk human papillomavirus was detected by self- and clinician-directed methods in 83% of the women with cervical intraepithelial neoplasia, grade 2/3. The 2 sequential swabs trend toward better detection of high-risk types of human papillomavirus than all other techniques for women with normal histologic factors (P = .0736, by McNemar's chi(2) test). Ninety-four percent of women would accept self-sampling for their yearly cervical screen. CONCLUSION: Self-sampling is equivalent to clinician sampling for the detection of high-risk human papillomavirus and is acceptable to women as a yearly screen.
引用
收藏
页码:365 / 373
页数:9
相关论文
共 26 条
[1]  
[Anonymous], DIAGNOSTIC MOL PATHO
[2]   Self administered tampons can be used to diagnose sexually transmitted diseases [J].
Bowden, FJ ;
Paterson, BA ;
Garland, SM ;
Tabrizi, S ;
Fairley, CK .
BRITISH MEDICAL JOURNAL, 1997, 314 (7078) :446-446
[3]   Hybrid Capture II-based human papillomavirus detection, a sensitive test to detect in routine high-grade cervical lesions: a preliminary study on 1518 women [J].
Clavel, C ;
Masure, M ;
Bory, JP ;
Putaud, I ;
Mangeonjean, C ;
Lorenzato, M ;
Gabriel, R ;
Quereux, C ;
Birembaut, P .
BRITISH JOURNAL OF CANCER, 1999, 80 (09) :1306-1311
[4]  
Coutlee F, 1997, J MED VIROL, V51, P42, DOI 10.1002/(SICI)1096-9071(199701)51:1<42::AID-JMV7>3.0.CO
[5]  
2-S
[6]   Human papillomavirus testing for primary cervical cancer screening [J].
Cuzick, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (01) :108-109
[7]   TAMPONS - A NOVEL PATIENT-ADMINISTERED METHOD FOR THE ASSESSMENT OF GENITAL HUMAN PAPILLOMAVIRUS INFECTION [J].
FAIRLEY, CK ;
CHEN, SJ ;
TABRIZI, SN ;
QUINN, MA ;
MCNEIL, JJ ;
GARLAND, SM .
JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (06) :1103-1106
[8]   Assessing gains in diagnostic utility when human papillomavirus testing is used as an adjunct to Papanicolaou smear in the triage of women with cervical cytologic abnormalities [J].
Franco, EL ;
Ferenczy, A .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1999, 181 (02) :382-386
[9]   COMPARISON OF CYTOBRUSH AND CERVICOVAGINAL LAVAGE SAMPLING METHODS FOR THE DETECTION OF GENITAL HUMAN PAPILLOMAVIRUS [J].
GOLDBERG, GL ;
VERMUND, SH ;
SCHIFFMAN, MH ;
RITTER, DB ;
SPITZER, C ;
BURK, RD .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1989, 161 (06) :1669-1672
[10]   Genotyping of 27 human papillomavirus types by using L1 consensus PCR products by a single-hybridization, reverse line blot detection method [J].
Gravitt, PE ;
Peyton, CL ;
Apple, RJ ;
Wheeler, CM .
JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (10) :3020-3027