Methylene blue-mediated photodynamic therapy: A possible alternative treatment for oral lichen planus

被引:78
作者
Aghahosseini, F [1 ]
Arbabi-Kalati, F [1 ]
Fashtami, LA [1 ]
Djavid, GE [1 ]
Fateh, M [1 ]
Beitollahi, JM [1 ]
机构
[1] Univ Tehran Med Sci, Dept Oral Med, Fac Dent, Tehran, Iran
关键词
methylene blue; oral lichen planus; pain severity; photodynamic therapy; sign score;
D O I
10.1002/lsm.20278
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background and Objectives: In this study, methylene blue-mediated photodynamic therapy (MB-PDT) was used as a possible alternative method for the treatment of oral lichen planus (OLP). Study Design/Materials and Methods: Thirteen patients with 26 OLP lesions were enrolled in this study. Patients were instructed to gargle a 5% methylene blue solution in water for 5 minutes. Ten minutes later, irradiation was performed by laser light (lambda = 632 nm, light exposure dose = 120 J/cm(2)). Lesions were evaluated pre and post-operatively and at follow-up sessions by changes in sign and symptom (pain) scores, and size of lesions. Results: Improvement in sign scores was achieved in 16 lesions. Four keratotic lesions disappeared completely. There was a statistically significant decrease in sign and symptom scores 1 week after treatment and at follow-up sessions up to 12 weeks. Average reduction in size of lesions was 44.3%. Conclusion: MB-PDT seems to be an effective alternative treatment for control of OLP. In our opinion, this preliminary result warrant further studies in order to show the efficacy of MB-PDT in control of OLP for a longer period of time.
引用
收藏
页码:33 / 38
页数:6
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