Striatal glutamate and the conversion to psychosis: a prospective 1H-MRS imaging study

被引：69

作者：

de la Fuente-Sandoval, Camilo ^{[1
,2
]}

Leon-Ortiz, Pablo ^{[1
]}

Azcarraga, Mariana ^{[1
]}

Favila, Rafael ^{[3
]}

Stephano, Sylvana ^{[2
]}

Graff-Guerrero, Ariel ^{[4
,5
,6
]}

机构：

[1] Inst Nacl Neurol & Neurocirug, Expt Psychiat Lab, Mexico City, DF, Mexico

[2] Inst Nacl Neurol & Neurocirug, Neuropsychiat Dept, Mexico City, DF, Mexico

[3] GE Healthcare, MR Adv Applicat, Mexico City, DF, Mexico

[4] Univ Toronto, Multimodal Neuroimaging Schizophrenia Grp, Res Imaging Ctr, Schizophrenia Program, Toronto, ON M5S 1A1, Canada

[5] Univ Toronto, Geriatr Mental Hlth Program, Ctr Addict & Mental Hlth, Toronto, ON M5S 1A1, Canada

[6] Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2013年 / 16卷 / 02期

关键词：

Associative-striatum; glutamate; H-1-MRS; prodromal; psychosis; PRODROMAL SYMPTOMS; EPISODE PSYCHOSIS; DOPAMINE RELEASE; SCHIZOPHRENIA; PREDICTION; HYPOTHESIS;

D O I：

10.1017/S1461145712000314

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Increased glutamate levels in the associative-striatum have been described in subjects at ultra-high risk for psychosis (UHR); nevertheless, it is unclear whether this abnormality predicts the conversion to psychosis. Nineteen subjects at UHR and 26 controls were studied using proton magnetic resonance spectroscopy. Subjects at UHR were clinically followed for 2 yr. Seven UHR subjects (37%) transitioned to a psychotic disorder and the remaining 12 did not exhibit psychotic symptoms at the most recent follow-up. The psychosis transition group had higher glutamate levels compared to both non-transition and control groups (p=0.02 and p<0.01, respectively; effect size 1.39). These pilot findings suggest that the conversion to psychosis is associated with increased glutamate levels in the associative-striatum.

引用

页码：471 / 475

页数：5

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