Heavier group-2-element catalyzed hydroamination of carbodiimides

被引：72

作者：

Lachs, Jennifer R. ^{[1
]}

Barrett, Anthony G. M. ^{[1
]}

Crimmin, Mark R. ^{[1
]}

Kociok-Koehn, Gabriele ^{[2
]}

Hill, Michael S. ^{[2
]}

Mahon, Mary F. ^{[2
]}

Procopiou, Panayiotis A. ^{[3
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[3] GlaxoSmithKline Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2008年 / 26期

基金：

英国工程与自然科学研究理事会;

关键词：

hydroamination; quanidine; guanidinate; alkaline earth amides;

D O I：

10.1002/ejic.200800613

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The heteroleptic calcium amide [{ArNC(Me)CHC(Me)-NAr}Ca{N(SiMe3)(2)}(THF)] (Ar = 2,6-diisopropylphenyl) and the homoleptic heavier alkaline earth amides, [M{N(SiMe3)(2)}(2)(THF)(2)] (M = Ca, Sr and Ba) are reported as competent pre-catalysts for the hydroamination of 1,3-carbodiimides. Whilst the reaction scope is currently limited to reactions of aromatic amines with 1,3-dialkylcarbodiimides, in most cases preparations in hydrocarbon solvents proceed rapidly at room temperature with catalyst loadings as low as 0.2 mol-% and the guanidine reaction products crystallize directly from the reaction mixture. Initial studies are consistent with the intermediacy of heavier group-2 guanidinate complexes. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).

引用

页码：4173 / 4179

页数：7

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