Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

被引：56

作者：

Sassatelli, M

Bouchikhi, F

Messaoudi, S

Anizon, F

Debiton, E

Barthomeuf, C

Prudhomme, M

Moreau, P

机构：

[1] Univ Clermont Ferrand, CNRS, Lab SEESIB, UMR 6504, F-63177 Aubiere, France

[2] Univ Auvergne, Ctr Jean Perrin, INSERM, UMR 484,Lab Pharmacog Biotechnol, F-63005 Clermont Ferrand, France

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 01期

关键词：

indigoids; isoindigos; antiproliferative activities;

D O I：

10.1016/j.ejmech.2005.10.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

in the course of structure-activity relationship studies, diversely substituted 1-(beta-(D)-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies. (c) 2005 Elsevier SAS. All rights reserved.

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页码：88 / 100

页数：13

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