Water-soluble 2-amino-1,8-naphthyridine as a novel DNA binding photosensitizer for one-electron oxidation of DNA

被引：4

作者：

Nakatani, K ^{[1
]}

Sando, S ^{[1
]}

Yoshida, K ^{[1
]}

Saito, I ^{[1
]}

机构：

[1] Kyoto Univ, Fac Engn, Dept Synth Chem & Biol Chem, CREST, Kyoto 6068501, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(99)01189-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

DNA binding and photoinduced DNA cleaving properties of water-soluble naphthyridine derivative 1 were investigated. The photoinduced cleavage of DNA was studied by both PAGE and product analysis, indicating that the DNA cleavage proceeds via one-electron oxidation pathway. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：6029 / 6032

页数：4

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