State of the art for cardiotoxicity due to chemotherapy and to targeted therapies: A literature review

被引：74

作者：

Berardi, Rossana ^{[1
]}

Caramanti, Miriam ^{[1
]}

Savini, Agnese ^{[1
]}

Chiorrini, Silvia ^{[1
]}

Pierantoni, Chiara ^{[1
]}

Onofri, Azzurra ^{[1
]}

Ballatore, Zelmira ^{[1
]}

De Lisa, Mariagrazia ^{[1
]}

Mazzanti, Paola ^{[1
]}

Cascinu, Stefano ^{[1
]}

机构：

[1] Univ Politecn Marche, Azienda Ospedaliero Univ Ospedali Riuniti Umberto, I-60126 Ancona, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2013年 / 88卷 / 01期

关键词：

Cardiotoxicity; Anticancer therapy; Cardiovascular toxicity; Targeted therapies; Chemotherapy; HIGH-DOSE CHEMOTHERAPY; BREAST-CANCER; CARDIAC TOXICITY; CARDIOVASCULAR COMPLICATIONS; ANGIOGENESIS INHIBITORS; INDUCED CARDIOMYOPATHY; ATRIAL-FIBRILLATION; COLORECTAL-CANCER; HEART-FAILURE; RISK-FACTORS;

D O I：

10.1016/j.critrevonc.2013.02.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cardiotoxicity is a common complication of many anti-cancer agents and it remains a major limitation, strongly impacting the quality of life and the overall survival, regardless of the oncologic prognosis. Cardiotoxicity may occur during or shortly after treatment (within days or weeks), or it may become evident months, and sometimes years, after completion of chemotherapy. Cardiotoxicity associated with cancer therapies can range from asymptomatic subclinical abnormalities, including electrocardiographic changes and temporary left ventricular ejection fraction decline, to life-threatening events such as congestive heart failure or acute coronary syndromes. The aim of this review is to summarize potential cancer chemotherapeutics-related cardiovascular toxicities in adult cancer-patients and to suggest monitoring and treatment options for each agent, that can serve as a tool in the clinical practice. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：75 / 86

页数：12

共 90 条

[1]

Rescuing COX-2 inhibitors from the waste bin [J].