How the Dorsal gradient works: Insights from postgenome technologies

被引：100

作者：

Hong, Joung-Woo ^{[1
]}

Hendrix, David A. ^{[1
]}

Papatsenko, Dmitri ^{[1
]}

Levine, Michael S. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Ctr Integrat Genom, Dept Mol & Cell Biol, Div Genet Gen & Dev, Berkeley, CA 94720 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 51期

基金：

美国国家卫生研究院;

关键词：

Drosophila; regulatory code; embryo; morphogen;

D O I：

10.1073/pnas.0806476105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, we discuss how a gradient of the maternal transcription factor Dorsal produces complex patterns of gene expression across the dorsal-ventral (DV) axis of the early Drosophila embryo. The identification of 60-70 Dorsal target genes, along with the characterization of approximate to 35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles.

引用

页码：20072 / 20076

页数：5

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