Toxic effect of an antitumor drug paclitaxel on morphofunctional characteristics of the liver in rats

被引：14

作者：

Ermolaeva, L. A. ^{[1
]}

Dubskaya, T. Yu. ^{[1
]}

Fomina, T. I. ^{[1
]}

Vetoshkina, T. V. ^{[1
]}

Gol'dberg, V. E. ^{[1
]}

机构：

[1] Russian Acad Sci, Siberian Div, Tomsk Res Ctr, Inst Pharmacol, Tomsk 117901, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 145卷 / 02期

关键词：

paclitaxel; hepatotoxicity; laboratory rats;

D O I：

10.1007/s10517-008-0066-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Single intravenous injection of paclitaxel to rats in a maximum tolerated dose of 4.6 mg/kg was accompanied by permanent structural and functional changes in the liver. The observed changes were typical of nonspecific reactive hepatitis: infiltration with lymphocytes and macrophages, pyknosis, and focal fatty degeneration of hepatocytes. Liver enzyme activity increased in blood plasma.

引用

页码：263 / 265

页数：3

共 15 条

[1]

Avtandilov GG, 1990, MED MORPHOMETRY MANU

[2]

Bogush T. A., 2001, Voprosy Onkologii (St. Petersburg), V47, P662

[3]

The bioactive Taxol conformation on β-tubulin:: Experimental evidence from highly active constrained analogs [J].

Ganesh, T ;

Guza, RC ;

Bane, S ;

Ravindra, R ;

Shanker, N ;

Lakdawala, AS ;

Snyder, JP ;

Kingston, DGI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (27) :10006-10011

[4]

Understanding tubulin-Taxol interactions: Mutations that impart Taxol binding to yeast tubulin [J].

Gupta, ML ;

Bode, CJ ;

Georg, GI ;

Himes, RH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (11) :6394-6397

[5]

Horwitz Susan Band, 1993, Journal of the National Cancer Institute Monographs, V0, P55

[6]

KINZIRSKAYA YA, 2003, KLIN MED MOSCOW, P11

[7]

LARIONOVA VB, 2004, VESTN INTENSIVN TER, P1

[8]

LYU BN, 2000, CANC PROBLEM 21 CENT, P415

[9]

Effects of taxol on isolated rat hepatocyte metabolism [J].

Manzano, A ;

Roig, T ;

Bermudez, J ;

Bartrons, R .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1996, 271 (06) :C1957-C1962

[10]

Comparison of pharmacokinetics and pharmacodynamics of docetaxel and cisplatin in elderly and non-elderly patients: Why is toxicity increased in elderly patients? [J].

Minami, H ;

Ohe, Y ;

Niho, S ;

Goto, K ;

Ohmatsu, H ;

Kubota, K ;

Kakinuma, R ;

Nishiwaki, Y ;

Nokihara, H ;

Sekine, I ;

Saijo, N ;

Hanada, K ;

Ogata, H .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (14) :2901-2908

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