Synthesis, molecular modeling, and biology of the 1-benzyl derivative of APDC - An apparent mGluR6 selective ligand

被引：35

作者：

Tuckmantel, W

Kozikowski, AP

Wang, SM

Pshenichkin, S

Wroblewski, JT

机构：

[1] GEORGETOWN UNIV,MED CTR,DRUG DISCOVERY LAB,INST COGNIT & COMPUTAT SCI,WASHINGTON,DC 20007

[2] GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL,WASHINGTON,DC 20007

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(97)00068-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of the 1-benzyl derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-benzyl-APDC) starting from cis-4-hydroxy-D-proline is disclosed together with a study of the activity of this compound at metabotropic glutamate receptors (mGluRs). The compound was found to display good mGluR6 selectivity, and may thus be a useful pharmacological research tool. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：601 / 606

页数：6

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