A new synthetic analogue of the bracken ultimate carcinogen: Elevation of stability and alteration of DNA alkylation site selectivity

被引：5

作者：

Kigoshi, H

Kitamura, Y

Fujita, T

Ohashi, H

Atsumi, T

Takagi, J

Mutou, T

Yamada, K

Kusakabe, T

Sasaki, D

Sugiura, Y

机构：

[1] NAGOYA UNIV,FAC SCI,DEPT CHEM,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN

[2] KYOTO UNIV,CHEM RES INST,UJI,KYOTO 611,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(97)00572-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The benzodienone 4 as a stable analogue of the bracken ultimate carcinogen (2) has been designed and synthesized. In the reaction with DNA the compound 4 was found to give only the N-7 alkylated product of guanine and no N-3 alkylated product of adenine and reveal guanine-selective cleavage in contrast to the natural dienone 2. (C) 1997 Elsevier Science Ltd.

引用

页码：3235 / 3238

页数：4

共 8 条

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