Can Nutraceuticals Prevent Alzheimer's Disease? Potential Therapeutic Role of a Formulation Containing Shilajit and Complex B Vitamins

被引：32

作者：

Carrasco-Gallardo, Carlos ^{[1
,2
]}

Farias, Gonzalo A. ^{[1
]}

Fuentes, Patricio ^{[3
,4
]}

Crespo, Fernando ^{[5
]}

Maccioni, Ricardo B. ^{[1
,2
]}

机构：

[1] ICC, Int Ctr Biomed, Santiago, Chile

[2] Univ Chile, Lab Cellular & Mol Neurosci, Fac Sci, Santiago, Chile

[3] Hosp Salvador, Neurol Serv, Cognit Neurol & Dementia Unit, Santiago, Chile

[4] Univ Chile, Geriatr Sect, Dept Med, Clin Hosp, Santiago, Chile

[5] Univ Valparaiso, Sch Ind Engn, Fac Engn, Santiago, Chile

来源：

ARCHIVES OF MEDICAL RESEARCH | 2012年 / 43卷 / 08期

关键词：

Alzheimer's disease; Tau protein; Nutraceuticals; Functional foods; Shilajit; Fulvic acid; AMYLOID HYPOTHESIS; FULVIC-ACID; TAU; HOMOCYSTEINE; PROTEIN; ENCAPSULATION; AGGREGATION; PROGRESS; HEALTH; FACTS;

D O I：

10.1016/j.arcmed.2012.10.010

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Alzheimer's disease (AD) is a brain disorder displaying a prevalence and impact in constant expansion. This expansive and epidemic behavior is concerning medical and public opinion while focusing efforts on its prevention and treatment. One important strategy to prevent this brain impairment is based on dietary changes and nutritional supplements, functional foods and nutraceuticals. In this review we discuss the potential contributions of shilajit and complex B vitamins to AD prevention. We analyze the status of biological studies and present data of a clinical trial developed in patients with mild AD. Studies suggest that shilajit and its active principle fulvic acid, as well as a formula of shilajit with B complex vitamins, emerge as novel nutraceutical with potential uses against this brain disorder. (c) 2012 IMSS. Published by Elsevier Inc.

引用

页码：699 / 704

页数：6

共 56 条

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