Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

被引：621

作者：

Bonkowski, Michael S. ^{[1
]}

Sinclair, David A. ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Dept Genet, Boston, MA 02115 USA

[2] Univ New South Wales, Dept Pharmacol, Sydney, NSW 2052, Australia

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2016年 / 17卷 / 11期

基金：

美国国家卫生研究院;

关键词：

LIFE-SPAN EXTENSION; HIGH-FAT DIET; SMALL-MOLECULE ACTIVATORS; CALORIC RESTRICTION; CAENORHABDITIS-ELEGANS; NICOTINAMIDE RIBOSIDE; RESVERATROL SUPPLEMENTATION; GENE-EXPRESSION; CELL-SURVIVAL; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1038/nrm.2016.93

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The sirtuins (SIRT1-7) are a family of nicotinamide adenine dinucleotide (NAD(+))-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol and SRT2104 or with NAD(+) precursors, have improved organ function, physical endurance, disease resistance and longevity. Trials in non-human primates and in humans have indicated that STACs may be safe and effective in treating inflammatory and metabolic disorders, among others. These advances have demonstrated that it is possible to rationally design molecules that can alleviate multiple diseases and possibly extend lifespan in humans.

引用

页码：679 / 690

页数：12

共 200 条

[1]

Longitudinal Trajectories of Arterial Stiffness and the Role of Blood Pressure The Baltimore Longitudinal Study of Aging [J].

AlGhatrif, Majd ;

Strait, James B. ;

Morrell, Chris H. ;

Canepa, Marco ;

Wright, Jeanette ;

Elango, Palchamy ;

Scuteri, Angelo ;

Najjar, Samer S. ;

Ferrucci, Luigi ;

Lakatta, Edward G. .

HYPERTENSION, 2013, 62 (05) :934-941

[2]

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae [J].

Anderson, RM ;

Bitterman, KJ ;

Wood, JG ;

Medvedik, O ;

Sinclair, DA .

NATURE, 2003, 423 (6936) :181-185

[3]

Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels [J].

Anderson, RM ;

Bitterman, KJ ;

Wood, JG ;

Medvedik, O ;

Cohen, H ;

Lin, SS ;

Manchester, JK ;

Gordon, JI ;

Sinclair, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (21) :18881-18890

[4]

The caloric restriction paradigm: Implications for healthy human aging [J].

Anderson, Rozalyn M. ;

Weindruch, Richard .

AMERICAN JOURNAL OF HUMAN BIOLOGY, 2012, 24 (02) :101-106

[5]

Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy [J].

Armour, Sean M. ;

Baur, Joseph A. ;

Hsieh, Sherry N. ;

Land-Bracha, Abigail ;

Thomas, Sheila M. ;

Sinclair, David A. .

AGING-US, 2009, 1 (06) :515-528

[6]

Åström SU, 2003, GENETICS, V163, P931

[7]

dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner [J].

Banerjee, Kushal Kr. ;

Ayyub, Champakali ;

Ali, Syed Zeeshan ;

Mandot, Vinesh ;

Prasad, Nagaraj G. ;

Kolthur-Seetharam, Ullas .

CELL REPORTS, 2012, 2 (06) :1485-1491

[8]

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice [J].

Banks, Alexander S. ;

Kon, Ning ;

Knight, Colette ;

Matsumoto, Michihiro ;

Gutierrez-Juarez, Roger ;

Rossetti, Luciano ;

Gu, Wei ;

Accili, Domenico .

CELL METABOLISM, 2008, 8 (04) :333-341

[9]

Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart [J].

Barger, J. L. ;

Kayo, T. ;

Pugh, T. D. ;

Prolla, T. A. ;

Weindruch, R. .

EXPERIMENTAL GERONTOLOGY, 2008, 43 (09) :859-866

[10]

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice [J].

Barger, Jamie L. ;

Kayo, Tsuyoshi ;

Vann, James M. ;

Arias, Edward B. ;

Wang, Jelai ;

Hacker, Timothy A. ;

Wang, Ying ;

Raederstorff, Daniel ;

Morrow, Jason D. ;

Leeuwenburgh, Christiaan ;

Allison, David B. ;

Saupe, Kurt W. ;

Cartee, Gregory D. ;

Weindruch, Richard ;

Prolla, Tomas A. .

PLOS ONE, 2008, 3 (06)

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