Normalizing results of 13C-urea breath testing for CO2 production rates in children

被引:70
作者
Klein, PD
Malaty, HM
Czinn, SJ
Emmons, SC
Martin, RF
Graham, DY
机构
[1] DiaSorin Inc, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
[3] Vet Adm Med Ctr, Houston, TX 77211 USA
[4] Rainbow Babies & Childrens Hosp, Cleveland, OH 44106 USA
[5] Marchem Associates Inc, Concord, MA USA
关键词
children; CO2; production; Helicobacter pylori; C-13-urea breath test; urea hydrolysis rate;
D O I
10.1097/00005176-199909000-00011
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: The C-13-urea breath test detects the presence of Helicobacter pylori from an enrichment of breath (CO2)-C-13, which, in turn, is critically dependent on the amount of dilution by endogenous CO2 production. The production of CO2 differs according to age (adults > children), sex (male > female) weight, and height. The cutoff value of 2.4 Delta% (delta over baseline, DOE) for the C-13-urea breath test, defined in adults, does not take into account actual CO, production. Therefore, this cutoff value (2.4 Delta%) may or may not be appropriate for children. The purpose of this study was to determine a cutoff value that would provide accurate results in pediatric patients, independent of their differences in anthropometric parameters. Methods: Estimates of CO2 production were combined with DOE values to calculate the host-dependent urea hydrolysis rate. Results: Calculated as urea hydrolysis rate, the cutoff range for adults was 10.4 to 10.9 mu g/min. Individual ranges were concentric (men, 9.6-10.9 mu g/min; women, 8.5-12.2 mu g/min). Results in studies of 312 children show that a urea hydrolysis rate of more than 10 mu g/min may also be appropriate to predict H. pylori infection. Conclusion: Calculating C-13-urea breath test values as urea hydrolysis rate removes the effect of individual anthropometric differences on test outcome and provides a single cutoff value for pediatric patients of all ages.
引用
收藏
页码:297 / 301
页数:5
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