Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat

被引:263
作者
Haynes, AC [1 ]
Jackson, B
Overend, P
Buckingham, RE
Wilson, S
Tadayyon, M
Arch, JRS
机构
[1] SmithKline Beecham Pharmaceut, Vasc Biol, Harlow CM19 5AD, Essex, England
[2] SmithKline Beecham Pharmaceut, Stat Sci, Harlow CM19 5AD, Essex, England
[3] SmithKline Beecham Pharmaceut, Funct Gene Anal, Harlow CM19 5AD, Essex, England
关键词
orexins; i.c.v; administration; feeding; light-dark cycle;
D O I
10.1016/S0196-9781(99)00105-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two novel hypothalamic neuropeptides, orexin-A and -B, are suggested to regulate feeding. A single intracerebroventricular injection of orexin-A (23.4 nmol), administered 3 h into the light phase, increased feeding in satiated rats and prolonged feeding in fasted rats; it also increased feeding when given 6 h into, but not at the start of, the dark phase. An 8-day intracerebroventricular infusion with orexin-A (18 nmol/day) increased daytime feeding on days 2 and 8, but nocturnal feeding was reduced and there was no change in 24 h intake. Orexin-B had no effects. These results demonstrate a circadian variation in feeding responses to orexin-A. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:1099 / 1105
页数:7
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