Fibroblasts as target cells for DEB gene therapy

被引：11

作者：

Chen, Mei ^{[1
]}

Woodley, David T. ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, Canc Res Labs, Dept Dermatol, Los Angeles, CA 90033 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2006年 / 126卷 / 04期

关键词：

D O I：

10.1038/sj.jid.5700216

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Dystrophic epidermolysis bullosa (DEB) is due to mutations in the type VII collagen (C7) gene. Potential therapies for DEB include (i) ex vivo gene therapy and (ii) intradermal injection of gene-corrected DEB fibroblasts, lentiviral vectors expressing C7 or recombinant C7 itself. With regard to molecular engineering, the dermal fibroblast has advantages over epidermal keratinocytes for delivering C7 to DEB patients.

引用

页码：708 / 710

页数：3

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