Synthesis and cytotoxicity of the dihydrated complex of oxaliplatin

被引：11

作者：

Videhult, P

Yachnin, J

Jerremalm, E

Lewensohn, R

Ehrsson, H ^{[1
]}

机构：

[1] Karolinska Hosp, SE-17176 Stockholm, Sweden

[2] Karolinska Hosp, Dept Oncol, Radiumhemmet, SE-17176 Stockholm, Sweden

[3] Karolinska Hosp, Karolinska Inst, Dept Pathol & Oncol, SE-17176 Stockholm, Sweden

来源：

CANCER LETTERS | 2002年 / 180卷 / 02期

关键词：

oxaliplatin; aquated product; cytotoxicity; lung cancer cell line;

D O I：

10.1016/S0304-3835(02)00002-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A new way of synthesizing the dihydrated oxaliplatin complex (DOC) is presented and its cytotoxicity is compared to that of oxaliplatin and cisplatin. By hydrolyzing oxaliplatin in aqueous sodium hydroxide at 70degreesC, DOC was formed in less than I h. Cytotoxicity was studied in the non-small cell lung cancer cell line A549 using the fluorescent microculture cytotoxic assay. Oxaliplatin and cisplatin had similar cytotoxicity profiles, whereas DOC was found to be considerably more toxic, The cytotoxicity of oxaliplatin might, at least in part, be mediated through the formation of DOC. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：191 / 194

页数：4

共 12 条

[1] KINETICS OF THE REACTION OF CIS-PLATINUM COMPOUNDS WITH DNA INVITRO [J].