A Population Approach to Precision Medicine

被引：104

作者：

Khoury, Muin J. ^{[1
,2
]}

Gwinn, Marta L. ^{[1
]}

Glasgow, Russell E. ^{[2
]}

Kramer, Barnett S. ^{[3
]}

机构：

[1] CDC, Off Publ Hlth Genom, Atlanta, GA 30333 USA

[2] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA

[3] NCI, Canc Prevent Div, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF PREVENTIVE MEDICINE | 2012年 / 42卷 / 06期

关键词：

GENOMIC MEDICINE; PUBLIC-HEALTH; CANCER; AGENDA; CHALLENGES; PREVENTION; SCIENCES; FUTURE; CARE;

D O I：

10.1016/j.amepre.2012.02.012

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The term P4 medicine is used to denote an evolving field of medicine that uses systems biology approaches and information technologies to enhance wellness rather than just treat disease. Its four components include predictive, preventive, personalized, and participatory medicine. In the current paper, it is argued that in order to fulfill the promise of P4 medicine, a "fifth P" must be integrated-the population perspective-into each of the other four components. A population perspective integrates predictive medicine into the ecologic model of health; applies principles of population screening to preventive medicine; uses evidence-based practice to personalize medicine; and grounds participatory medicine on the three core functions of public health: assessment, policy development, and assurance. Population sciences-including epidemiology; behavioral, social, and communication sciences; and health economics, implementation science, and outcomes research-are needed to show the value of P4 medicine. Balanced strategies that implement both population-and individual-level interventions can best maximize health benefits, minimize harm, and avoid unnecessary healthcare costs. (Am J Prev Med 2012; 42(6): 639-645) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine

引用

页码：639 / 645

页数：7

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