Role of FliC and FliD flagellar proteins of Clostridium difficile in adherence and gut colonization

被引：211

作者：

Tasteyre, A ^{[1
]}

Barc, MC ^{[1
]}

Collignon, A ^{[1
]}

Boureau, H ^{[1
]}

Karjalainen, T ^{[1
]}

机构：

[1] Univ Paris Sud, Fac Pharm, Dept Microbiol, F-92296 Chatenay Malabry, France

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 12期

关键词：

D O I：

10.1128/IAI.69.12.7937-7940.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In vitro and in vivo adhesive properties of flagella and recombinant flagellin FliC and flagellar cap FliD proteins of Clostridium difficile were analyzed. FliC, FliD, and crude flagella adhered in vitro to axenic mouse cecal mucus. Radiolabeled cultured cells bound to a high degree to FliD and weakly to flagella deposited on a membrane. The tissue association in the mouse cecum of a nonflagellated strain was 10-fold lower than that of a flagellated strain belonging to the same serogroup, confirming the role of flagella in adherence.

引用

页码：7937 / 7940

页数：4

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