Effect of amitriptyline on gastrointestinal function and brain-gut peptides: A double-blind trial

被引:124
作者
Huang, Wei [1 ]
Jiang, Shu-Man [1 ]
Jia, Lin [1 ]
You, Le-Qing [1 ]
Huang, Yao-Xing [1 ]
Gong, Yan-Mei [2 ]
Wang, Gui-Qin [3 ]
机构
[1] Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Dept Gastroenterol, Guangzhou 510180, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Dept Radiol, Guangzhou 510180, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Dept Stat, Guangzhou 510180, Guangdong, Peoples R China
关键词
Amitriptyline; Orocecal transit time; Visceral hypersensitivity; Gastric emptying; Brain-gut peptides; IRRITABLE-BOWEL-SYNDROME; NEUROPEPTIDE-Y; CLINICAL-TRIAL; TRANSIT-TIME; DYSPEPSIA; SYMPTOMS; GHRELIN; STOMACH; STRESS;
D O I
10.3748/wjg.v19.i26.4214
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
AIM: To study the effects of low-dose amitriptyline (AMT) on gastrointestinal function and brain-gut peptides in healthy Chinese volunteers. METHODS: This was a double-blind, randomised, placebo-controlled, two-period cross-over trial. Twenty-eight healthy volunteers were randomised and administered 1-wk treatments of AMT (12.5 mg tid) or placebo. Before and during the final two days of treatment, gastric emptying, proximal gastric accommodation and visceral sensitivity were measured by drinking-ultrasonography test; the orocecal transit time (OCTT) was measured by lactulose hydrogen breath test, and fasting blood was collected. Plasma levels of ghrelin, motilin and neuropeptide Y (NPY) were measured by enzyme-linked immunosorbent assay kits. RESULTS: AMT slowed the OCTT (109.2 +/- 29.68 min vs 96.61 +/- 23.9 min, P = 0.004) but did not affect liquid gastric emptying and had no effect on proximal gastric accommodation. AMT resulted in decreases in the visual analogue scale (VAS) for difficulty in drinking 600 and 800 mL of water (3.57 +/- 0.94 vs 2.98 +/- 0.85, 5.57 +/- 0.82 vs 4.57 +/- 0.98, P < 0.01 for both), although it had no significant effect on the VAS for difficulty in drinking 200 mL and 400 mL of water. AMT significantly increased the plasma ghrelin level (442.87 +/- 176.79 pg/mL vs 526.87 +/- 158.44 pg/mL, P = 0.04) and the neuropeptide-Y level (890.15 +/- 131.46 pg/mL vs 965.64 +/- 165.63 pg/mL, P = 0.03), whereas it had no effect on the MTL level. CONCLUSION: Low-dose AMT could slow OCTT, make the stomach less sensitive and increase the plasma levels of ghrelin and NPY. Thus, we recommend the use of low-dose AMT for functional gastrointestinal disorders. (C) 2013 Baishideng. All rights reserved.
引用
收藏
页码:4214 / 4220
页数:7
相关论文
共 27 条
[1]
ELEVATED MOTILIN LEVELS IN PATIENTS TREATED WITH ANTI-DEPRESSANT AND NEUROLEPTIC DRUGS [J].
ALLEN, JM ;
CHRISTOFIDES, ND ;
CRAMER, PA ;
STEINERT, J ;
BLOOM, SR .
BRITISH JOURNAL OF PSYCHIATRY, 1982, 141 (JUL) :27-29
[2]
ERYTHROMYCIN ACCELERATES GASTRIC-EMPTYING BY INDUCING ANTRAL CONTRACTIONS AND IMPROVED GASTRODUODENAL COORDINATION [J].
ANNESE, V ;
JANSSENS, J ;
VANTRAPPEN, G ;
TACK, J ;
PEETERS, TL ;
WILLEMSE, P ;
VANCUTSEM, E .
GASTROENTEROLOGY, 1992, 102 (03) :823-828
[3]
Sensitivity to change, discriminative performance, and cutoff criteria to define remission for embedded short scales of the Hamilton depression rating scale (HAMD) [J].
Ballesteros, Javier ;
Bobes, Julio ;
Bulbena, Antonio ;
Luque, Antonio ;
Dal-Re, Rafael ;
Ibarra, Nora ;
Guemes, Ltziar .
JOURNAL OF AFFECTIVE DISORDERS, 2007, 102 (1-3) :93-99
[4]
Bodé S, 2004, J PEDIATR GASTR NUTR, V39, P378, DOI 10.1097/00005176-200410000-00014
[5]
Effects of amitriptyline on gastric sensorimotor function and postprandial symptoms in healthy individuals: A randomized, double-blind, placebo-controlled trial [J].
Bouras, Ernest P. ;
Talley, Nicholas J. ;
Camilleri, Michael ;
Burton, Duane D. ;
Heckman, Michael G. ;
Crook, Julia E. ;
Richelson, Elliott .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2008, 103 (08) :2043-2050
[6]
Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double-blind placebo-controlled study [J].
Braak, B. ;
Klooker, T. K. ;
Wouters, M. M. ;
Lei, A. ;
van den Wijngaard, R. M. ;
Boeckxstaens, G. E. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2011, 34 (06) :638-648
[7]
Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome [J].
Camilleri, Michael ;
Mckinzie, Sanna ;
Busciglio, Irene ;
Low, Phillip A. ;
Sweetser, Seth ;
Burtow, Duane ;
Baxter, Kari ;
Ryks, Michael ;
Zinsmeister, Alan R. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2008, 6 (07) :772-781
[8]
Current Medical Treatments of Dyspepsia and Irritable Bowel Syndrome [J].
Camilleri, Michael ;
Tack, Jan F. .
GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2010, 39 (03) :481-+
[9]
Migraine preventive drug-induced weight gain may be mediated by effects on hypothalamic peptides: The results of a pilot study [J].
Caproni, Stefano ;
Corbelli, Ilenia ;
Pini, Luigi Alberto ;
Cupini, Maria Letizia ;
Calabresi, Paolo ;
Sarchielli, Paola .
CEPHALALGIA, 2011, 31 (05) :543-549
[10]
A role for neuropeptide Y in the gender-specific gastrointestinal, corticosterone and feeding responses to stress [J].
Forbes, S. ;
Herzog, H. ;
Cox, H. M. .
BRITISH JOURNAL OF PHARMACOLOGY, 2012, 166 (08) :2307-2316