Expanding the diversity of unnatural cell-surface sialic acids

被引：116

作者：

Luchansky, SJ

Goon, S

Bertozzi, CR ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Mat Sci, Berkeley, CA 94720 USA

来源：

CHEMBIOCHEM | 2004年 / 5卷 / 03期

关键词：

azides; glycans; glycoconjugates; ketones; oligosaccharides; sialic acid; Staudinger ligation;

D O I：

10.1002/cbic.200300789

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Introduction of sialic acid analogues to cells, rather than their upstream N-acetylmannosamine (ManNAc) precursors, improves the delivery of bioorthogonal functional groups to the cell surface and enables the incorporation of photoactivatable azides into glycoconjugates (see scheme).

引用

收藏

页码：371 / 374

页数：4

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