Proliferation and differentiation of neural stem cells irradiated with X-rays in logarithmic growth phase

被引：21

作者：

Isono, Mayu ^{[1
,2
]}

Otsu, Masahiro ^{[1
,3
]}

Konishi, Teruaki ^{[2
]}

Matsubara, Kana ^{[4
]}

Tanabe, Toshiaki

Nakayama, Takashi ^{[1
,5
]}

Inoue, Nobuo ^{[1
]}

机构：

[1] Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Frontier Hlth Sci, Lab Regenerat Neurosci, Tokyo 158, Japan

[2] Natl Inst Radiol Sci, Res Dev & Support Ctr, Dept Tech Support & Dev, Chiba 260, Japan

[3] Kyorin Univ, Sch Med, Dept Chem, Tokyo, Japan

[4] Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Radiol Sci, Tokyo 158, Japan

[5] Yokohama City Univ, Sch Med, Dept Biochem, Yokohama, Kanagawa 232, Japan

来源：

NEUROSCIENCE RESEARCH | 2012年 / 73卷 / 03期

关键词：

Neural stem cells; Embryonic stem cells; X-irradiation; Capabilities for proliferation and differentiation; HIPPOCAMPAL NEUROGENESIS; NEURONAL DIFFERENTIATION; BRAIN; EXPRESSION; APOPTOSIS; DYSFUNCTION; PHENOTYPES; DAMAGE; MICE;

D O I：

10.1016/j.neures.2012.04.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Exposure of the fetal brain to ionizing radiation causes congenital brain abnormalities. Normal brain formation requires regionally and temporally appropriate proliferation and differentiation of neural stem cells (NSCs) into neurons and glia. Here, we investigated the effects of X-irradiation on proliferating homogenous NSCs prepared from mouse ES cells. Cells irradiated with X-rays at a dose of 1 Gy maintained the capabilities for proliferation and differentiation but stopped proliferation temporarily. In contrast, the cells ceased proliferation following irradiation at a dose of >5 Gy. These results suggest that irradiation of the fetal brain at relatively low doses may cause congenital brain abnormalities as with relatively high doses. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：263 / 268

页数：6

共 28 条

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