Ciliary proteins and exencephaly

被引：20

作者：

Katsanis, N ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

来源：

NATURE GENETICS | 2006年 / 38卷 / 02期

关键词：

D O I：

10.1038/ng0206-135

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Neural tube defects (NTDs) represent a broad and complex class of brain malformations, and despite much progress in understanding their etiology, many facets of neural tube development and closure remain obscure. Two new studies report the identification of the first two genes responsible for Meckel-Gruber syndrome, one of the major contributors to syndromic NTDs, and implicate defective cilia in its pathogenesis.

引用

页码：135 / 136

页数：2

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