Long non-coding RNA HOTAIR: A novel oncogene (Review)

被引：214

作者：

Yu, Xin ^{[1
,2
,3
]}

Li, Zheng ^{[1
]}

机构：

[1] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing 100730, Peoples R China

[2] Chinese Acad Med Sci, Fuwai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China

[3] Peking Union Med Coll, Beijing 100037, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2015年 / 12卷 / 04期

基金：

中国国家自然科学基金;

关键词：

HOTAIR; long non-coding RNAs; oncogene; cancer; INDEPENDENT PROGNOSTIC MARKER; TO-MESENCHYMAL TRANSITION; POOR-PROGNOSIS; BREAST-CANCER; EXPRESSION; POLYCOMB; CARCINOMA; PROGRESSION; METASTASIS; MECHANISMS;

D O I：

10.3892/mmr.2015.4161

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Long non-coding RNAs (lncRNAs) have been found to be pervasively transcribed in the genome and are critical regulators of the epigenome. Increasing evidence suggests that lncRNAs are aberrantly expressed in several types of human cancer and that they are important in the initiation, development and metastasis of human cancer. Previous studies have revealed that HOX transcript antisense intergenic RNA (HOTAIR) was frequently upregulated in various types of cancer, including breast cancer, esophageal cancer, lung cancer and gastric cancer. In addition, patients with high expression levels of HOTAIR have a significantly poorer prognosis, compared with those with low levels of expression. HOTAIR is involved in the control of cell apoptosis, growth, metastasis, angiogenesis, DNA repair and tumor cells metabolism. The present review provides an overview of the current knowledge concerning the role of HOTAIR in tumor development and progression.

引用

页码：5611 / 5618

页数：8

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