Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: potential cancer theranostics

被引：132

作者：

Cheng, Shih-Hsun ^{[1
,3
]}

Lee, Chia-Hung ^{[2
]}

Yang, Chung-Shi ^{[2
]}

Tseng, Fan-Gang ^{[3
]}

Mou, Chung-Yuan ^{[4
]}

Lo, Leu-Wei ^{[1
]}

机构：

[1] Natl Hlth Res Inst, Div Med Engn Res, Zhunan 350, Taiwan

[2] Natl Hlth Res Inst, Ctr Nanomed Res, Zhunan 350, Taiwan

[3] Natl Tsing Hua Univ, Inst NanoEngn & MicroSyst, Hsinchu 300, Taiwan

[4] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2009年 / 19卷 / 09期

关键词：

DRUG-DELIVERY; CONTROLLED-RELEASE; POLYMERIC NANOPARTICLES; SINGLET OXYGEN; CARRIER SYSTEM; PHOTOSENSITIZERS; PHOSPHORESCENCE; MODULATION; AVERMECTIN; PARTICLES;

D O I：

10.1039/b816636f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Functionalization of mesoporous silica nanoparticles (MSNs) with Pd-porphyrins for cancer cell photodynamic therapy is reported. The composite platform, MSN-PdTPP, expands the role of Pd-porphyrins from their routine use as phosphorescence probes for oxygen sensing/imaging (diagnostics) to that of novel nano-photosensitizers for cancer cell phototherapy (therapeutics). The utility of MSN-PdTPP in the phototherapeutic treatment of MDA-MB-231 breast cancer cells is also evaluated, suggesting it is a promising cancer theranostic platform.

引用

页码：1252 / 1257

页数：6

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