Subclinical vitamin D deficiency in neonates: Definition and response to vitamin D supplements

被引:106
作者
Zeghoud, F [1 ]
Vervel, C [1 ]
Guillozo, H [1 ]
WalrantDebray, O [1 ]
Boutignon, H [1 ]
Garabedian, M [1 ]
机构
[1] HOP ST JOSEPH, DEPT PEDIAT & MATERNITE, COMPIEGNE, FRANCE
关键词
secondary hyperparathyroidism; serum calcidiol concentrations; vitamin D deficiency; vitamin D supplementation; infancy; calcitriol; 25-hydroxyvitamin D; cholecalciferol; ergocalciferol; 1,25-dihydroxyvitamin D;
D O I
10.1093/ajcn/65.3.771
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
To determine the biological criteria for neonatal vitamin D deficiency, serum 25-hydroxyvitamin D (calcidiol), parathyroid hormone (PTH), calcium, phosphates, and alkaline phosphatase (ALP) activity were measured during the winter-spring period in 80 healthy neonates and their mothers 3-6 d after delivery. A longitudinal 3-mo survey of the serum biology of 52 of these neonates consuming formula was also performed to test the influence of their neonatal vitamin D status on the effects of two oral ergocalciferol supplements (500 and 1000 IU or 12.5 and 25 mu g/d). At birth, 63.7% of the infants had calcidiol concentrations less than or equal to 30 nmol/L. Most of them had no other biological sign evocative of vitamin D deficiency, but 14 neonates had low calcidiol concentrations and serum PTH concentrations > 60 ng/L, the upper limit of the adult normal range. They also had a significantly lower mean serum calcium concentration than did neonates with calcidiol concentrations > 30 nmol/L. On the basis of the association of low calcidiol concentrations (less than or equal to 30 nmol/L) and high PTH concentrations (> 60 ng/L) as criteria for vitamin D deficiency, 24% of the neonates born To unsupplemented mothers were found to be vitamin D-deficient. Neonatal vitamin D status influenced the response of the infants to vitamin D supplements. Neonates with no sign of vitamin D deficiency showed similar changes in their serum calcidiol, calcium, phosphate, and PTH concentrations and ALP activity and no toxic effect (hypercalcemia or highly elevated calcidiol concentration) was observed whatever their vitamin D intake. In contrast, neonates with subclinical vitamin D deficiency had normalized serum PTH within I mo only when they were given 1000 IU ergocalciferol (25 mu g)/d in addition to their formula.
引用
收藏
页码:771 / 778
页数:8
相关论文
共 41 条
[1]   25-HYDROXYVITAMIN-D LEVELS DURING BREAST-FEEDING WITH OR WITHOUT MATERNAL OR INFANTILE SUPPLEMENTATION OF VITAMIN-D [J].
ALAHOUHALA, M .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1985, 4 (02) :220-226
[2]  
[Anonymous], JOURN PAR PED MED SC
[3]   25-HYDROXYVITAMIN-D AND ITS BINDING-PROTEIN IN MATERNAL AND CORD SERUM [J].
BOUILLON, R ;
VANBAELEN, H ;
DEMOOR, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1977, 45 (04) :679-684
[4]   INTRAUTERINE VITAMIN-D NUTRITION AND POSTNATAL-GROWTH IN ASIAN INFANTS [J].
BROOKE, OG ;
BUTTERS, F ;
WOOD, C .
BMJ-BRITISH MEDICAL JOURNAL, 1981, 283 (6298) :1024-1024
[5]  
BROOKE OG, 1980, J HUM NUTR, V34, P355
[6]   VITAMIN-D SUPPLEMENTS IN PREGNANT ASIAN WOMEN - EFFECTS ON CALCIUM STATUS AND FETAL GROWTH [J].
BROOKE, OG ;
BROWN, IRF ;
BONE, CDM ;
CARTER, ND ;
CLEEVE, HJW ;
MAXWELL, JD ;
ROBINSON, VP ;
WINDER, SM .
BMJ-BRITISH MEDICAL JOURNAL, 1980, 280 (6216) :751-754
[7]   OBSERVATIONS ON THE VITAMIN-D STATE OF PREGNANT ASIAN WOMEN IN LONDON [J].
BROOKE, OG ;
BROWN, IRF ;
CLEEVE, HJW ;
SOOD, A .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1981, 88 (01) :18-26
[8]   CONGESTIVE-HEART-FAILURE CAUSED BY VITAMIN-D DEFICIENCY [J].
BRUNVAND, L ;
HAGA, P ;
TANGSRUD, SE ;
HAUG, E .
ACTA PAEDIATRICA, 1995, 84 (01) :106-108
[9]  
CHALVON DA, 1994, ARCH PEDIATR, V1, P855
[10]   VITAMIN-D(3) AND CALCIUM TO PREVENT HIP-FRACTURES IN ELDERLY WOMEN [J].
CHAPUY, MC ;
ARLOT, ME ;
DUBOEUF, F ;
BRUN, J ;
CROUZET, B ;
ARNAUD, S ;
DELMAS, PD ;
MEUNIER, PJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (23) :1637-1642