Pathogenesis of type 2 diabetes - Insulin resistance

被引：76

作者：

Boden, G

机构：

[1] Temple Univ, Sch Med, Div Endocrinol Diabet Metab, Philadelphia, PA 19122 USA

[2] Temple Univ, Sch Med, Gen Clin Res Ctr, Philadelphia, PA 19122 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2001年 / 30卷 / 04期

关键词：

D O I：

10.1016/S0889-8529(05)70216-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article addresses the role of insulin resistance in the pathogenesis of type 2 diabetes. The major causes of acquired insulin resistance including aging, pregnancy, lack of physical activity, and obesity are discussed briefly. The role of free fatty acids (FFAs) as a link between obesity and insulin resistance/type 2 diabetes is discussed in detail. Evidence is provided showing that increased plasma FFA levels produce insulin resistance dosage dependently, acutely, and chronically. Mechanisms by which FFA can cause insulin resistance are outlined. Lastly, normalizing plasma FFA levels is proposed as a new approach to reducing insulin resistance and the risk for type 2 diabetes mellitus, and atherosclerotic vascular disease.

引用

收藏

页码：801 / +

页数：16

相关论文

共 69 条

[1] Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats - A mechanism for inhibiting glycogen synthesis [J].

Avignon, A ;

Yamada, K ;

Zhou, XP ;

Spencer, B ;

Cardona, O ;

SabaSiddique, S ;

Galloway, L ;

Standaert, ML ;

Farese, RV .

DIABETES, 1996, 45 (10) :1396-1404

[2] DIABETES IN IDENTICAL-TWINS - A STUDY OF 200 PAIRS [J].

BARNETT, AH ;

EFF, C ;

LESLIE, RDG ;

PYKE, DA .

DIABETOLOGIA, 1981, 20 (02) :87-93

[3] TOWARD PHYSIOLOGICAL UNDERSTANDING OF GLUCOSE-TOLERANCE - MINIMAL-MODEL APPROACH [J].

BERGMAN, RN .

DIABETES, 1989, 38 (12) :1512-1527

[4] EQUIVALENCE OF THE INSULIN SENSITIVITY INDEX IN MAN DERIVED BY THE MINIMAL MODEL METHOD AND THE EUGLYCEMIC GLUCOSE CLAMP [J].

BERGMAN, RN ;

PRAGER, R ;

VOLUND, A ;

OLEFSKY, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (03) :790-800

[5] CARBOHYDRATE AND LIPID-METABOLISM IN MIDDLE-AGED, PHYSICALLY WELL-TRAINED MEN [J].

BJORNTORP, P ;

SCHERSTEN, T ;

HOLM, J ;

GUSTAFSON, A ;

GRIMBY, G ;

RENSTROM, P ;

FAHLEN, M .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1972, 21 (11) :1037-+

[6] EFFECTS OF FAT ON GLUCOSE-UPTAKE AND UTILIZATION IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES [J].

BODEN, G ;

CHEN, XH .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (03) :1261-1268

[7] Fuel metabolism in pregnancy and in gestational diabetes mellitus [J].

Boden, G .

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, 1996, 23 (01) :1-+

[8] MECHANISMS OF FATTY ACID-INDUCED INHIBITION OF GLUCOSE-UPTAKE [J].

BODEN, G ;

CHEN, XH ;

RUIZ, J ;

WHITE, JV ;

ROSSETTI, L .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (06) :2438-2446

[9] EFFECTS OF AGE AND BODY-FAT ON INSULIN RESISTANCE IN HEALTHY-MEN [J].

BODEN, G ;

CHEN, XH ;

DESANTIS, RA ;

KENDRICK, Z .

DIABETES CARE, 1993, 16 (05) :728-733

[10] Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects [J].

Boden, G ;

Lebed, B ;

Schatz, M ;

Homko, C ;

Lemieux, S .

DIABETES, 2001, 50 (07) :1612-1617

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