Role of chemokines and chemokine receptors in the gastrointestinal tract

被引：86

作者：

Ajuebor, MN ^{[1
]}

Swain, MG ^{[1
]}

机构：

[1] Univ Calgary, Dept Med, Fac Med, Liver Unit,Gastrointestinal Res Grp, Calgary, AB T2N 4N1, Canada

来源：

IMMUNOLOGY | 2002年 / 105卷 / 02期

关键词：

D O I：

10.1046/j.1365-2567.2002.01309.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The pathological association between leucocytes and gastrointestinal diseases has long been recognized. Chemokines are a large family of chemotactic cytokines whose fundamental role is the recruitment of leucocytes to tissues. Although chemokines and their receptors are considered to be mediators of inflammation and tissue injury in several inflammatory diseases, their precise role in the pathophysiology of gastrointestinal diseases remains incompletely understood. Nonetheless, by virtue of their expression and localization at sites of gastrointestinal tissue injury and inflammation, a number of investigators have suggested a vital role for chemokines and their receptors in the pathophysiology of gastrointestinal diseases. This short review examines the role of chemokines and their receptors in the gastrointestinal tract with an emphasis on their involvement in the regulation of intestinal and hepatic inflammation.

引用

页码：137 / 143

页数：7

共 75 条

[1]

Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model [J].