Immunohistochemical colocalization of GTP cyclohydrolase I in the nigrostriatal system with tyrosine hydroxylase

被引：26

作者：

Nagatsu, I ^{[1
]}

Arai, R ^{[1
]}

Sakai, M ^{[1
]}

Yamawaki, Y ^{[1
]}

Takeuchi, T ^{[1
]}

Karasawa, N ^{[1
]}

Nagatsu, T ^{[1
]}

机构：

[1] FUJITA HLTH UNIV, SCH MED, INST COMPREHENS MED SCI, TOYOAKE, AICHI 47011, JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 224卷 / 03期

关键词：

aromatic L-amino acid decarboxylase; colocalization; GTP cyclohydrolase I; immunohistochemistry; mouse; nigrostriatal system; tyrosine hydroxylase; ultrastructure; AMINO-ACID DECARBOXYLASE; TRANSGENIC MICE; AXON TERMINALS; GENE; SEROTONIN; DOPAMINE; NEURONS; RAT;

D O I：

10.1016/S0304-3940(97)00159-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immunohistochemical colocalization of GTP cyclohydrolase I (GCH) in the mouse nigrostriatal system with tyrosine hydroxylase or aromatic L-amino acid decarboxylase in the somata and terminals of GCH-positive catecholaminergic neurons are proved for the first time by a double-labeling immunofluorescence method with a confocal laser-scanning microscope. GCH-immunoreactive somata in the mouse substantia nigra have synaptic contacts with monoaminergic and non-monoaminergic terminals. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：185 / 188

页数：4

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