Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity

被引：195

作者：

Turan-Zitouni, G ^{[1
]}

Sivaci, M

Kiliç, FS

Erol, K

机构：

[1] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey

[2] Osmangazi Univ, Fac Med, Dept Pharmacol, TR-26480 Eskisehir, Turkey

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2001年 / 36卷 / 7-8期

关键词：

antipyrine; triazoles; analgesic activity;

D O I：

10.1016/S0223-5234(01)01252-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of some triazolyl-antipyrine derivatives starting from 4-chloroacetamidoantipyrine and 3-(aryloxyalkyl)-4-ethyl/phenyl-5-mercapto-1,2,4-triazoles is described. The chemical structures of the compounds were elucidated by IR, H-1-NMR and mass spectral studies. These compounds were tested for analgesic activity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：685 / 689

页数：5

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